At Klarity, we understand how discouraging it can feel when depression doesn’t improve with traditional medications or therapy alone. You’re not alone—and there are advanced treatment options available.
We offer Spravato® (esketamine), an FDA-approved, in-office treatment for adults with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts. Unlike traditional antidepressants, Spravato works by targeting NMDA receptors in the brain—helping to restore balance, improve mood, and deliver relief more rapidly.
Administered under medical supervision in a safe and supportive setting, Spravato provides a new path forward for patients who have not found success with standard treatments.
With convenient locations in Castleton and Greenwood, Indiana, Klarity is proud to offer innovative, evidence-based care designed to help you feel better and regain a sense of control in your life.
What is Spravato®?
Spravato® (esketamine) is a FDA approved prescription nasal spray derived from ketamine that works differently from traditional antidepressants. Rather than targeting serotonin or dopamine, it acts on the brain’s glutamate system—a key pathway involved in mood, learning, and emotional regulation.
By enhancing communication between brain cells and promoting neuroplasticity, Spravato helps the brain form new, healthier connections. This process can lead to meaningful improvements in mood, clarity, and thought patterns—often more rapidly than standard medications.
Treatment is administered in-office under medical supervision, where patients are monitored throughout each session to ensure a safe and supportive experience.
How Spravato® Works
Spravato works by enhancing neuroplasticity—helping the brain form new, healthier connections and restore communication between mood-regulating regions. By targeting the brain’s glutamate system, it can lead to improvements in mood, motivation, and mental clarity, often more quickly than traditional medications.
What to Expect During Treatment
Spravato is self-administered as a nasal spray under the guidance of our trained medical team. You’ll be comfortably seated in a private treatment room while the medication is given in a calm, supportive environment.
Monitoring & Recovery
After administration, you’ll remain in the clinic for approximately two hours while our team monitors your response, vital signs, and overall comfort. This observation period ensures you feel stable, safe, and ready before leaving.
Treatment Timeline
Many patients begin to notice improvement after the first few sessions, with continued progress over several weeks. Treatment is typically structured as a series of sessions, with frequency gradually decreasing as symptoms improve.
Benefits of Spravato
Balanced Mood
Balanced mood and improved resilience
Enhanced Results
Enhanced results when combined with treatments like Ketamine or TMS
Improved Energy
Improved energy and focus and sleep
Increase Motivation
Increased energy and motivation and stamina
Sleep Improvement
Improves sleep quality and recovery
Stress Reduction
Supports nervous system balance
Enhanced Focus
Enhanced mental focus and confidence
Spravato offers a new approach for individuals who haven’t found relief with traditional treatments—helping improve symptoms and restore a sense of stability and hope.
- Rapid relief from depressive symptoms and suicidal ideation
- Effective for patients who haven’t responded to traditional antidepressants
- Improves mood, focus, and emotional stability
- Reduces feelings of hopelessness and fatigue
- Safe, FDA-approved, and administered under medical supervision
- Non-invasive with minimal downtime
- Can be used alongside oral antidepressants for enhanced results
Spravato provides a new path forward — one that targets the root of depression to promote lasting healing and resilience.
You may be a good candidate for Spravato if you:
- Have been diagnosed with major depressive disorder (MDD)
- Have not found relief after trying two or more antidepressant medications
- Are experiencing treatment-resistant depression (TRD)
- Struggle with persistent depressive symptoms, including hopelessness or suicidal thoughts
- Are looking for a fast-acting, non-invasive treatment option
- Prefer a structured, in-office therapy with medical supervision
Spravato is designed for adults seeking meaningful improvement in mood, energy, and overall well-being—especially when traditional treatments have not been effective.
What to Expect During Spravato® Treatment
01
Comprehensive Consultation
Your journey begins with a detailed consultation with one of our experienced providers. We’ll review your symptoms, treatment history, and goals to determine if Spravato is the right option and develop a personalized care plan.
02
In-Office Treatment Session
During your appointment, you’ll self-administer Spravato nasal spray under the guidance of our trained medical team. You’ll be seated comfortably in a private treatment room designed to help you feel relaxed and supported throughout the experience.
03
Monitoring & Recovery
After administration, you’ll remain in the clinic for approximately two hours while our team monitors your vital signs, response to treatment, and overall comfort. This ensures your safety and allows time for the medication’s effects to gradually stabilize before you leave.
04
Ongoing Care & Progress Tracking
Spravato is given as part of a structured treatment plan, typically starting with more frequent sessions and gradually decreasing over time. Our team will track your progress closely, adjust your plan as needed, and support you throughout your journey to ensure the best possible outcomes.
Book Your Spravato® Consultation in Indiana
If you’ve tried antidepressants without success, you’re not alone—and there are new options available. Spravato® may offer the breakthrough you’ve been looking for, especially when traditional treatments haven’t provided enough relief.
At Klarity, we specialize in personalized, evidence-based care designed to help you regain stability, clarity, and a renewed sense of hope.
Take the first step today.
Schedule your Spravato consultation at our Castleton or Greenwood locations and find out if this treatment is right for you.
Locations
Greenwood
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Castleton
Frequently Asked Questions
At Klarity, we’re committed to helping you take control of your mental health with compassionate, expert care. Our psychiatric medication management services are designed to provide:
Both treatments work on the brain’s glutamate system, but Spravato is FDA-approved and administered as a nasal spray under supervision, while ketamine is delivered intravenously. Some patients respond better to one or a combination of both.
Each visit lasts about two hours, including administration and observation time.
Many patients experience mood improvements after the first few treatments, with continued progress throughout their treatment series.
In many cases, yes. Because Spravato is FDA-approved for treatment-resistant depression, insurance coverage is often available. Our team will help you verify your benefits.
Absolutely. Spravato can be safely used alongside oral antidepressants, therapy, or other treatments like TMS or ketamine infusions for enhanced outcomes.
Spravato is FDA-approved and often covered by insurance for qualifying patients. Klarity will review your coverage options, verify benefits, and discuss flexible payment solutions during your consultation.
We believe financial considerations should never stand in the way of your healing — our team is here to guide you through every step of the process.
Why Choose Klarity Wellness Clinic?
Klarity is a trusted provider of advanced, evidence-based mental health treatments in Indiana. Led by Dr. Melissa Reed, MD, our multidisciplinary team delivers care that is both innovative and deeply compassionate.
We specialize in treatment-resistant mood disorders, offering personalized programs that may include Spravato, ketamine infusions, Exomind TMS, and hormone optimization to help you achieve full-spectrum wellness.
Our goal is to help you regain hope, restore mental balance, and reclaim your quality of life — all in a calm, supportive setting.
Related Treatments
Klarity offers several complementary services designed to enhance and sustain your emotional well-being.
Most insurances accepted
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