At Klarity, we understand how frustrating it can be to struggle with depression that doesn’t improve through traditional medications or therapy alone. That’s why we offer Spravato® (esketamine) — an FDA-approved, in-office treatment specifically designed for individuals with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts.
Spravato works differently from traditional antidepressants by targeting NMDA receptors in the brain, helping to restore balance, improve mood, and promote rapid relief from symptoms of depression.
With convenient locations in Castleton and Greenwood, Indiana, Klarity Wellness Clinic provides a safe, comfortable environment where patients can receive cutting-edge care that promotes healing from the inside out.
What is Spravato?
Spravato® (esketamine) is a prescription nasal spray derived from ketamine and approved by the FDA for adults with treatment-resistant depression or depression accompanied by suicidal thoughts.
Unlike traditional antidepressants that act on serotonin or dopamine, Spravato works by modulating the brain’s glutamate system — a key pathway involved in learning, memory, and emotional regulation. This mechanism helps rebuild and strengthen neural connections, resulting in noticeable improvements in mood and thought patterns, often within hours or days.
Spravato is administered in-office under medical supervision, ensuring comfort and safety at every step.
How It Works
Spravato is self-administered under the guidance of our trained medical staff. The medication is delivered through a nasal spray while you relax in one of our private treatment suites.
After each administration, you’ll remain comfortably seated for about two hours while our care team monitors your response and ensures you feel grounded before leaving.
Spravato activates glutamate receptors to increase neuroplasticity — the brain’s ability to adapt, form new connections, and repair communication between mood-regulating regions.
Many patients begin noticing improvement in mood, motivation, and clarity after just two to three sessions, with continued enhancement over several weeks.
Benefits of Spravato
Enhanced Focus
Enhanced mental focus and confidence
Balanced Mood
Balanced mood and improved resilience
- Rapid relief from depressive symptoms and suicidal ideation
- Effective for patients who haven’t responded to traditional antidepressants
- Improves mood, focus, and emotional stability
- Reduces feelings of hopelessness and fatigue
- Safe, FDA-approved, and administered under medical supervision
- Non-invasive with minimal downtime
- Can be used alongside oral antidepressants for enhanced results
Spravato provides a new path forward — one that targets the root of depression to promote lasting healing and resilience.
You may be a candidate for Spravato if you:
- Have been diagnosed with major depressive disorder (MDD)
- Have not achieved relief from at least two antidepressant medications
- Experience treatment-resistant depression (TRD)
- Struggle with suicidal thoughts or feelings of hopelessness
- Want a fast-acting, non-invasive treatment option
- Prefer an in-office therapy under medical supervision
Spravato is appropriate for adults seeking rapid, reliable improvement in mood and motivation when other options haven’t worked.
What to Expect During Treatment
01
Initial Consultation
Your journey begins with a detailed evaluation by one of our healthcare providers. We’ll review your medical and mental health history, current medications, and goals to determine if Spravato is right for you.
02
Treatment Sessions
Each session is administered in our private treatment suite. You’ll be monitored closely by our clinical team for comfort and safety throughout the infusion. You can expect a calm, meditative experience that promotes emotional reset and relaxation.
03
After Treatment
Following your session, you’ll be observed briefly before returning home the same day. Many patients notice improved mood and mental clarity within hours, with cumulative benefits building after each infusion. We require a ride home after each session, as you will not be allowed to drive or operate any machinery until after a restful night’s sleep.
Book Your Spravato Consultation in Indiana
If you’ve tried antidepressants without success, Spravato may be the breakthrough you’ve been searching for. At Klarity Wellness Clinic, we specialize in helping individuals find hope again through advanced, personalized treatments.
Contact us today to schedule your Spravato consultation at our Castleton or Greenwood, Indiana locations — and discover a faster path to relief, recovery, and renewed emotional health.
Locations
Greenwood
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Castleton
Frequently Asked Questions
At Klarity, we’re committed to helping you take control of your mental health with compassionate, expert care. Our psychiatric medication management services are designed to provide:
Both treatments work on the brain’s glutamate system, but Spravato is FDA-approved and administered as a nasal spray under supervision, while ketamine is delivered intravenously. Some patients respond better to one or a combination of both.
Each visit lasts about two hours, including administration and observation time.
Many patients experience mood improvements after the first few treatments, with continued progress throughout their treatment series.
In many cases, yes. Because Spravato is FDA-approved for treatment-resistant depression, insurance coverage is often available. Our team will help you verify your benefits.
Absolutely. Spravato can be safely used alongside oral antidepressants, therapy, or other treatments like TMS or ketamine infusions for enhanced outcomes.
Spravato is FDA-approved and often covered by insurance for qualifying patients. Klarity will review your coverage options, verify benefits, and discuss flexible payment solutions during your consultation.
We believe financial considerations should never stand in the way of your healing — our team is here to guide you through every step of the process.
Why Choose Klarity Wellness Clinic?
Klarity is a trusted provider of advanced, evidence-based mental health treatments in Indiana. Led by Dr. Melissa Reed, MD, our multidisciplinary team delivers care that is both innovative and deeply compassionate.
We specialize in treatment-resistant mood disorders, offering personalized programs that may include Spravato, ketamine infusions, Exomind TMS, and hormone optimization to help you achieve full-spectrum wellness.
Our goal is to help you regain hope, restore mental balance, and reclaim your quality of life — all in a calm, supportive setting.
Related Treatments
Klarity offers several complementary services designed to enhance and sustain your emotional well-being.
Most insurances accepted
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